Experts debate North Korea's missile goals and capability









WASHINGTON — When North Korea launched a small satellite into orbit last month for the first time, U.S. officials called it a cover for a more ominous goal: a ballistic missile that could carry a nuclear weapon as far as the continental United States.


But North Korea is a long way from building a workable intercontinental missile and, at the current pace of testing, it could take many years before they are close, missile technology experts say.


"They could put up something that would look like a credible missile but ... it's not really much of a threat," said Boston-based physicist David Wright, who follows the North Korean program for the nonpartisan Union of Concerned Scientists. "They have no idea whether it's going to blow up on the launch pad or dump one of their precious nuclear weapons into the Pacific Ocean."





This week, Bill Richardson, a former governor of New Mexico, is visiting Pyongyang, the North Korean capital, with Eric Schmidt, the executive chairman of Google, on what they are calling a private humanitarian trip. Richardson said Wednesday that he was pressing the government to stop all missile launches and nuclear tests and to allow more cellphones and an open Internet for its citizens.


Some experts outside the U.S. government contend that North Korea's failure-prone missile program is essentially a bluff aimed at spurring concessions from the international community.


U.S. intelligence officials disagree. They say North Korea is intent on developing a capability to threaten the West with nuclear weapons. In 2011, then-Defense Secretary Robert Gates said North Korea would have a missile that could strike the continental United States by 2016, although some U.S. officials believe that timetable has now slipped.


The North Koreans "haven't tested a lot, which slows development," said a U.S. official familiar with the latest intelligence. "But they're still moving forward."


North Korean leader Kim Jong Un hailed the Dec. 12 satellite launch in a televised New Year's Day speech, calling on the nation to rebuild its ailing economy "in the same spirit and mettle as were displayed in conquering space."


But progress has been halting. In recent years, North Korea has attempted one or two rocket tests annually, most of which failed. In April, a rocket carrying a satellite exploded 90 seconds after takeoff.


Building a dependable intercontinental ballistic missile would require "flight tests every other month, over several years," said Markus Schiller, who wrote a paper about the missile program in October for Rand Corp., a Santa Monica-based think tank. "First-generation long-range missiles require dozens of flight tests until they are reliable and accurate enough for deployment."


Schiller said in his Rand paper that the main purpose of the North's rocket launches is to deter the United States and South Korea, and "to gain strategic leverage in foreign politics."


The three-stage Unha rocket that put a small satellite into orbit last month "was developed as a satellite launcher and not as a weapon," Schiller said in a telephone interview from Germany. "The technology was only suited for satellite launch."


The rocket's third stage took a dog leg turn to avoid flying over Taiwan and the Philippines, said Brian Weeden, a former U.S. Air Force space expert now with the Secure World Foundation, a Washington think tank.


"That is definitely something more associated with a space launch than with a ballistic missile launch," he said. "It's not what you would expect to see with a missile test."


Any successful rocket launch could theoretically help North Korea improve its missile technology, Weeden said. But launching a satellite is easier than perfecting a missile that can carry a weapons payload into space and then deliver it to a specific target without burning up in the atmosphere.


Other analysts believe North Korea made a major technological advance with the satellite launch. Bruce Klingner, a former CIA analyst now at the Heritage Foundation, a Washington think tank, called it "a huge step forward in their capabilities."


Jeffrey Lewis, a nonproliferation expert at the nonpartisan Monterey Institute of International Studies, worries that North Korea is making just enough progress to be dangerous.


"The North Koreans might just be willing to deal with less reliable systems," he said. "They might just be happy with 50% reliability. My starting assumption is that they are serious, that this is something that they intend to build. I presume that they are competent enough that this is not an impossible missile."


ken.dilanian@latimes.com





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Go Ahead, Keep Being Mean to Celebrities on Twitter






We realize there’s only so much time one can spend in a day watching new trailers, viral video clips, and shaky cell phone footage of people arguing on live television. This is why every day The Atlantic Wire highlights the videos that truly earn your five minutes (or less) of attention. Today:  


RELATED: The Honey Boo Boo Nature Special; Everyone’s Favorite Sleepwalking Mom






We usually don’t condone being an impolite jerk to anyone, especially on social media. But we kind of make an exception because, well, if everyone was nice to everyone all of a sudden, we’d run out of fun Jimmy Kimmel segments where celebrities read their tweets:


RELATED: Ai Weiwei’s ‘Gangnam Style’ Isn’t Bad


RELATED: So Which Boyfriend Is Taylor Swift Singing About Now?


Oh man, this giant squid is like the most famous sea creature celebrity of the moment. And yes, it’s way freakier in motion:


RELATED: Katie Holmes Goes Bust on Broadway


RELATED: Justin Bieber is Coming to Town


So fine, this is sort of bending the rules per se because this isn’t really a video-video. It’s the Game of Thrones introduction with beatboxing by the Stark children. 


And finally, here is one minute of a man singing all the songs involving the word “baby.” And in case you were wondering, yes, Justin Bieber is officially in the Baby Pantheon of Music. 


Social Media News Headlines – Yahoo! News





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Adele to make post-baby debut at Golden Globes


BEVERLY HILLS, Calif. (AP) — Adele is coming to the Golden Globes.


The executive producer of the show says the 24-year-old Grammy-winning pop star is set to make her first post-baby appearance at Sunday's ceremony, where she is nominated for original song for the James Bond theme "Skyfall."


Adele welcomed her first child, with boyfriend Simon Konecki, in October. The singer has kept a low profile since announcing her pregnancy in June after sweeping the Grammy Awards last February with six wins.


Her single, "Skyfall," will compete at the Golden Globes with Taylor Swift's song from "The Hunger Games," Jon Bon Jovi's number from "Stand Up Guys," Keith Urban's track from "Act of Valor," and "Suddenly" from "Les Miserables."


The Globes will be presented Sunday at the Beverly Hilton Hotel.


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Pap Test May Prove Useful at Detecting More Types of Cancer, Study Suggests





The Pap test, which has prevented countless deaths from cervical cancer, may eventually help to detect cancers of the uterus and ovaries as well, a new study suggests.




For the first time, researchers have found genetic material from uterine or ovarian cancers in Pap smears, meaning that it may become possible to detect three diseases with just one routine test.


But the research is early, years away from being used in medical practice, and there are caveats. The women studied were already known to have cancer, and while the Pap test found 100 percent of the uterine cancers, it detected only 41 percent of the ovarian cancers. And the approach has not yet been tried in women who appear healthy, to determine whether it can find early signs of uterine or ovarian cancer.


On the other hand, even a 41 percent detection rate would be better than the status quo in ovarian cancer, particularly if the detection extends to early stages. The disease is usually advanced by the time it is found, and survival rates are poor. About 22,280 new cases were expected in the United States in 2012, and 15,500 deaths. Improved tests are urgently needed.


Uterine cancer has a better prognosis, but still kills around 8,000 women a year in the United States.


These innovative applications of the Pap test are part of a new era in which advances in genetics are being applied to the detection of a wide variety of cancers or precancerous conditions. Scientists are learning to find minute bits of mutant DNA in tissue samples or bodily fluids that may signal the presence of hidden or incipient cancers.


Ideally, the new techniques would find the abnormalities early enough to cure the disease or even prevent it entirely. But it is too soon to tell.


“Is this the harbinger of things to come? I would answer yes,” said Dr. Bert Vogelstein, director of the Ludwig Center for Cancer Genetics and Therapeutics at Johns Hopkins University, and a senior author of a report on the Pap test study published on Wednesday in the journal Science Translational Medicine. He said the genomes of more than 50 types of tumors had been sequenced, and researchers were trying to take advantage of the information.


Similar studies are under way or are being considered to look for mutant DNA in blood, stool, urine and sputum, both to detect cancer and also to monitor the response to treatment in people known to have the disease.


But researchers warn that such tests, used for screening, can be a double-edged sword if they give false positive results that send patients down a rabbit hole of invasive tests and needless treatments. Even a test that finds only real cancers may be unable to tell aggressive, dangerous ones apart from indolent ones that might never do any harm, leaving patients to decide whether to watch and wait or to go through surgery, chemotherapy and radiation with all the associated risks and side effects.


“Will they start recovering mutations that are not cancer-related?” asked Dr. Christopher P. Crum, a professor at Harvard Medical School who was not involved in the research.


But he also called the study a “great proof of principle,” and said, “Any whisper of hope to women who suffer from endometrial or ovarian cancer would be most welcome.”


DNA testing is already performed on samples from Pap tests, to look for the human papillomavirus, or HPV, which causes cervical cancer. Dr. Vogelstein and his team decided to try DNA testing for cancer. They theorized that cells or DNA shed from cancers of the ovaries and the uterine lining, or endometrium, might reach the cervix and turn up in Pap smears.


The team picked common mutations found in these cancers, and looked for them in tumor samples from 24 women with endometrial cancer and 22 with ovarian cancer. All the cancers had one or more of the common mutations.


Then, the researchers performed Pap tests on the same women, and looked for the same DNA mutations in the Pap specimens. They found the mutations in 100 percent of the women with endometrial cancer, but in only 9 of the 22 with ovarian cancer. The test identified two of the four ovarian cancers that had been diagnosed at an early stage.


Finally, the team developed a test that would look simultaneously for cancer-associated mutations in 12 different genes in Pap samples. Used in a control sample of 14 healthy women, the test found no mutations — meaning no false-positive results.


Dr. Luis A. Diaz, the other senior author of the report and an associate professor of oncology at Johns Hopkins, called the research a step toward a screening test that at first blush appears very effective at detecting endometrial cancer, though obviously less so at finding ovarian cancer.


“Probably one of the most exciting features of this approach,” Dr. Diaz said, “is that we wanted a test that would seamlessly integrate with routine medical practice that could be utilized with the same test that women get every day all over the world, the Pap smear.”


But, he added: “We can’t say it’s ready for prime time. Like all good science, it needs to be validated.”


He and other members of the team said it might be possible to improve the detection rate for ovarian cancer by looking for more mutations and by changing the technique of performing Pap tests to increase the likelihood of capturing cells from the ovary. The change might involve timing the test to a certain point in a woman’s monthly cycle, using a longer brush to collect cells from deeper within the cervix or prescribing a drug that would raise the odds of cells being shed from the ovary.


The technique also needs to be tested in much larger groups of women, including healthy ones, to find out whether it works, particularly at finding cancers early enough to improve survival. And studies must also find out whether it generates false positive results, or identifies cancers that might not actually need to be treated.


Michael H. Melner, a program director in molecular genetics and biochemistry for the American Cancer Society, called the research “very promising,” in part because it is based on finding mutations.


“It tells you not just that cancer is there, but which mutation is there,” Dr. Melner said. “As we learn more and more about which mutations are associated with more or less severe forms of cancer, it’s more information, and possibly more diagnostic.”


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Hedge fund takes 8.2% stake in Herbalife









Hedge fund Third Point took an 8.2% stake in Herbalife Ltd., becoming the latest firm to bet against hedge fund manager Bill Ackman, who has accused the direct seller of nutritional products of being a pyramid scheme.


Third Point, which had about $10 billion under management and is run by financier Daniel Loeb, has purchased 8.9 million Herbalife shares, according to a filing with the Securities and Exchange Commission.


Herbalife is fighting allegations made by Ackman, the founder of Pershing Square Capital Management, that it uses inflated pricing, misleading sales information and a complicated incentive structure to hide a pyramid scheme. Herbalife is preparing to lay out its rebuttal at an investor conference in New York on Thursday.








Quiz: How well do you remember 2012?


Additionally, Herbalife might be facing an investigation by the Securities and Exchange Commission, according to the Wall Street Journal. The inquiry, run out the SEC's New York office, will likely look into the company's sales practices.


Loeb's investment "sounds incredibly wise to us," Tim Ramey, an analyst with D.A. Davidson & Co., said while traveling in New York, where he plans to attend the Herbalife meeting. "The Ackman case doesn't have any merit. It attempts to prove the company's a pyramid scheme when the prima facie evidence is that it's not."


Ramey recommends buying the stock.


Herbalife closed up $1.60, or 4.2%, at $39.95 after earlier surging as much as 9.3%.


Barb Henderson, an Herbalife spokeswoman, declined to comment on the Third Point investment. Loeb didn't immediately respond to an email seeking details.


Ackman, who has sold short about 20 million Herbalife shares, said in a statement Wednesday that his goal was "to shine a spotlight on the company so that the world better understands the facts about Herbalife."


"The outcome of this investment is not about Pershing Square or anyone else who is long or short the stock," Ackman, Pershing Square's chief executive, said in the emailed statement. "To the extent another investor, long or short, brings additional sunlight to the situation, we welcome them."


Short selling refers to the practice of borrowing shares and selling them, with the goal of profiting by repurchasing them later at a lower price.





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Syria conflict blocks aid to 1 million needy, U.N. agency says









BEIRUT — The World Food Program said Tuesday that Syria's civil war has blocked the United Nations agency from delivering aid to at least 1 million people who are in desperate need of help.


The Syrian Arab Red Crescent, the U.N. agency's local partner, has been stretched to capacity and violence between forces loyal to President Bashar Assad and the armed opposition has prevented aid workers from reaching some needy Syrians, said Abeer Etefa, an agency spokeswoman.


Truck drivers have been reluctant to transport food into conflict areas, and World Food Program staff members have had to ride in armored vehicles to monitor food distribution in some areas, Etefa said.





She said the U.N. agency also has had difficulty accessing its main warehouse in Damascus, the capital.


"There are serious bread and fuel shortages across the country, with large numbers of Syrians who are displaced and seeking shelter," she said. "We are already helping 1.5 people million in Syria, but we estimate that 1 million are still in need of food assistance."


Damascus and surrounding areas have seen intense fighting. Airstrikes have targeted rebel-held areas, and antigovernment fighters have carried out assassinations and set off bombs in the city.


Conditions have forced the World Food Program to find alternative access points into Syria, including sending food overland from Lebanon instead of relying on the main harbor in Tartus. Shipments to the port were cut off after a shipping company refused to deliver there, but have since resumed.


An estimated 597,240 Syrian refugees are facing harsh winter weather, many equipped with only flimsy canvas tents and insufficient clothing. In northern Jordan, a riot broke out Tuesday over bread shortages at the Zaatari refugee camp near the Syrian border, an aid worker said. No more information was immediately available.


Zaatari has been inundated by heavy rain over the last two days, making some parts of the camp uninhabitable. Twenty-four families were moved to prefabricated huts because of mud and pools of water, said Mohammad Askar, a spokesman for the U.N. refugee agency.


"The problem is that there are only 2,500 of these prefabricated huts from Saudi Arabia. This is not enough to provide the necessary humanitarian assistance," Askar said.


Also Tuesday, Yarmouk, a sprawling enclave of mostly Palestinian refugees, was shelled and saw fighting between Syrian rebels and government supporters. The opposition Syrian Observatory for Human Rights, a Britain-based nongovernmental organization, said four people in the camp, in southern Damascus, were killed by shelling and a fifth by a sniper.


Syria's 21-month-old civil war has split Yarmouk's Palestinians into armed pro- and anti-Assad factions. In December, the camp was shelled as pro-rebel fighters tried to take it over and clashed with Assad's supporters.


Fourteen Palestinian factions issued a statement calling for calm and urging fighters to withdraw from the camp "in order not to bear the responsibility of the continuing displacement of [Yarmouk's] residents," the Associated Press reported.


ned.parker@latimes.com


Bulos is a special correspondent.





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James Franco Does His Best Justin Bieber






We realize there’s only so much time one can spend in a day watching new trailers, viral video clips, and shaky cell phone footage of people arguing on live television. This is why every day The Atlantic Wire highlights the videos that truly earn your five minutes (or less) of attention. Today:  


RELATED: All We Want for Christmas Is Jimmy Fallon and Mariah Carey Singing to Us






Remember when Justin Bieber was struggling for relevance and James Franco was the super serious, super educated actor destined for greatness? Well, Franco clearly doesn’t want you to:


RELATED: Dating Is Just So Depressing


RELATED: A Dubstep Birthday for Michael Jackson and One Soggy Koala


So what do you do when someone gets their dream wedding ruined by a doomed hot-air balloon ride? Well, if you’re the Today show, you make a macabre Wedding Crashers joke: 


RELATED: Ai Weiwei’s ‘Gangnam Style’ Isn’t Bad


RELATED: ‘What Makes You Beautiful’ Gets Beautiful


Here’s perhaps one of the better arguments against that trillion-dollar coin, courtesy of Homer Simpson and company:


And this guy seems pretty down on the squandered opulence of cruise ships:


Wireless News Headlines – Yahoo! News





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Bill Taylor to be awarded John A. Bonner Medal


LOS ANGELES (AP) — Visual effects supervisor Bill Taylor is being honored by the Academy of Motion Picture Arts and Sciences.


The academy says Taylor will be awarded the John A. Bonner Medal of Commendation at the Scientific and Technical Awards banquet Feb. 9 at the Beverly Hills Hotel.


The John A. Bonner Medal is named in honor of the late director of special projects at Warner Hollywood Studios. It's awarded for outstanding service and dedication in upholding the high standards of the motion picture academy.


Taylor's visual effects credits include such films as "Lawless," ''Public Enemies," ''Milk" and "Bruce Almighty."


Portions of the Scientific and Technical Awards presentations will be included in the Academy Awards broadcast on Feb. 24.


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Gaps Seen in Therapy for Suicidal Teenagers


Most adolescents who plan or attempt suicide have already gotten at least some mental health treatment, raising questions about the effectiveness of current approaches to helping troubled teenagers, according to the largest in-depth analysis to date of suicidal behaviors in American teenagers.


The study in the journal JAMA Psychiatry found that 55 percent of suicidal teenagers had received some therapy before they thought about suicide, planned it or tried to kill themselves, contradicting the widely held belief that suicide is due in part to a lack of access to treatment.


The findings, based on interviews with a nationwide sample of more than 6,000 teenagers and at least one parent of each, linked suicidal behavior to complex combinations of mood disorders like depression and behavior problems that include attention-deficit and eating disorders, as well as alcohol and drug abuse.


The study found that about one in eight teenagers had persistent suicidal thoughts at some point, and about a third of them had made a suicide attempt, usually within a year of having the idea.


Previous studies have had similar findings, based on smaller, regional samples. But the new study is the first to suggest, in a large nationwide sample, that access to treatment does not make a big difference.


The study suggests that effective treatment for severely suicidal teenagers must address not just mood disorders, but also behavior problems that can lead to impulsive acts, experts said. According to the Centers for Disease Control and Prevention, 1,386 people between the ages of 13 and 18 committed suicide in 2010, the latest year for which numbers are available.


“I think one of the take-aways here is that treatment for depression may be necessary but not sufficient to prevent kids from attempting suicide,” said Dr. David Brent, a professor of psychiatry at the University of Pittsburgh, who was not involved in the study. “We simply do not have empirically validated treatments for recurrent suicidal behavior.”


The report said nothing about whether the therapies given were state of the art, or carefully done, said Matt Nock, a professor of psychology at Harvard and the lead author; and it is possible that some of the treatments prevented suicide attempts. “But it’s telling us we’ve got a long way to go to do this right,” Dr. Nock said. His co-authors included Ronald C. Kessler of Harvard, and researchers from Boston University and Children’s Hospital Boston.


Margaret McConnell, a consultant in Alexandria, Va., said that her daughter Alice, who killed herself in 2006, at the age of 17, was getting treatment at the time. “I think there might have been some carelessness in the way the treatment was done,” Ms. McConnell said, “and I was trusting a 17-year-old to manage her own medication; we found out after we lost her that she wasn’t taking it regularly.”


In the study, researchers surveyed 6,483 adolescents from the ages of 13 to 18 and found that 9 percent of male teenagers and 15 percent of female teenagers experienced some stretch of having persistent suicidal thoughts. Among girls, 5 percent made suicide plans and 6 percent made at least one attempt (some were unplanned).


Among boys, 3 percent made plans and 2 percent carried out attempts – which tended to be more lethal than girls’ attempts.


(Suicidal thinking or behavior was virtually unheard-of before age 10.)


Over all, about one-third of teenagers with persistent suicidal thoughts went on to make an attempt to take their own lives.


Almost all of the suicidal adolescents in the study qualified for some psychiatric diagnosis, whether depression, phobias, or generalized anxiety disorder. Those with an added behavior problem – attention-deficit disorder, substance abuse, explosive anger – were more likely to act on thoughts of self-harm, the study found.


Doctors have tested a range of therapies to prevent or reduce recurrent suicidal behaviors, with mixed success. Medications can ease depression, but in some cases can increase suicidal thinking. Talk therapy can contain some behavior problems, but not all.


One approach, called dialectical behavior therapy, has proved effective in reducing hospitalizations and attempts in people with so-called borderline personality disorder, who are highly prone to self-harm, among others.


But suicidal teenagers who have a mixture of mood and behavior issues are difficult to reach. In one 2011 study, researchers at George Mason University reduced suicide attempts, hospitalizations, drinking and drug use among suicidal adolescent substance abusers. The study found that a combination of intensive treatments – talk therapy for mood problems, family-based therapy for behavior issues and patient-led reduction in drug use – was more effective that regular therapies.


“But that’s just one study, and it’s small,” Dr. Brent said. “We can treat components of the overall problem, but that’s about all.”


Ms. McConnell said that her daughter’s depression seemed mild and that there was no warning that she would take her life. “I think therapy does help a lot of people, if it’s handled right,” she said.


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Alcoa posts $242-million profit, in line with forecasts









Alcoa Inc.'s fourth-quarter earnings met Wall Street's expectations, and it sees slightly higher demand for aluminum this year.

Net income was $242 million, or 21 cents a share. That included one-time gains such as income from selling a hydroelectric project.

Without those gains, the company would have made 6 cents a share — exactly what analysts expected, according to FactSet — on revenue of $5.9 billion. Sales were higher than the $5.58 billion that analysts predicted.








In the fourth quarter of 2011, the company posted a loss of $191 million, or 18 cents a share, on revenue of $5.99 billion, and a loss after special items of 3 cents a share.

The weak global economy has hurt demand for aluminum used in a wide variety of products, including airplanes and soda cans. But Alcoa said Tuesday that it sees demand growing 7% in 2013, up from a 6% gain in 2012, with the best prospects in aerospace but slower improvement in autos, packaging, and building and construction materials.

The company said it hit record profits in its aluminum-rolling and product-making businesses while cutting costs in its mining and refining segment.

Chairman and Chief Executive Klaus Kleinfeld said the company overcame volatile aluminum prices and global economic weakness and was in "strong position to maximize profitable growth" in 2013.

Alcoa is the first company in the Dow Jones industrial average to report fourth-quarter earnings. Because it makes aluminum for so many key industries, investors study Alcoa's results for clues about the health and direction of the overall economy.

Alcoa shares ended regular trading unchanged at $9.10. In after-hours trading following the earnings report, the stock gained 14 cents to $9.24.





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